Papers - 2000-2004

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333. P.L. Luisi, P. Walde, M. Blocher, D. Liu

Research on the Origin of Life: Membrane-Assisted Polycondensations of Amino Acids and Peptides

Chimia 54, 52-53, 2000


334. P. L. Luisi

The Relevance of Supramolecular Chemistry for the Origin of Life

Advances in Supramolecular Chemistry 6, 287-307, 2000


335. P.R. Mittl, C. Deillon, D. Sargent, N. Liu, S. Klauser, R.M. Thomas, B. Gutte, M.G. Grutter

The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure

PNAS 97, 2562-2566, 2000


336. M. Blocher, D. Liu, P.L. Luisi

Liposome-Assisted Selective Polycondensation of a-Amino Acids and Peptides: the Case of Charged Liposomes

Macromolecules 33, 5787-5796, 2000


337. A. Fischer, T. Oberholzer, P.L. Luisi

Giant vesicles as models to study the interactions between membranes and proteins

Biochim. et Biophys. Acta 1467, 177-188, 2000


338. P.L. Luisi

L'assemblage des macromolecules

La Recherche 336, 24-29, 2000


339. D. Berti, P.L. Luisi, P. Baglioni

Molecular reecognition in supramolecular structures formed by phosphatidylnucleosides-based amphiphiles

Colloids and Surfaces A: Physico-Chem.Eng.Aspects 167, 95-103, 2000


340. S. Lang, F. Stuart, R.M. Thomas, J.W. Vrijbloed, J.A. Robinson

Analysis of Antibody A6 Binding to the Extracellular Interferon Receptor chain by Alanine- Scanning Mutagenesis with Phage Display.

Biochemistry 39, 15674-15685, 2000


341. P.L. Luisi, P. Walde (eds.)

Giant Vesicles, Perspectives in Supramolecular Chemistry

John Wiley & Sons Ltd., chichester, 2000


342. P. Walde

Enzymatic Reactions in Giant Vesicles

In: Giant Vesicles, Perspectives in Supramol. Chemistry (Luisi P.L., Walde P., eds), John Wiley & Sons Ltd., Chichester, 297-3111, 2000


343. P.L. Luisi

Why Giant Vesicles?

In: Giant Vesicles, Perspectives in Supramol. Chemistry (Luisi P.L., Walde P., eds), John Wiley &

Sons Ltd., Chichester, 3-9, 2000


344. A. Fischer, P.L. Luisi, T.Oberholzer, P. Walde

Formation of Giant Vesicles from Different Kinds of Lipids Using the Electroformation Method

In: Giant Vesicles, Perspectives in Supramol. Chemistry (Luisi P.L., Walde P., eds), John Wiley & Sons Ltd., Chichester, 37-43, 2000


345. A. Goto, A. Suzuki, H. Yoshioka, R. Goto, T. Imae, K. Yamazaki, P. Walde

Dynamic Aspects of Fatty Acid Vesicles: pH-induced Vesicle-Micelle Transition and Dilutioninduced Formation of Giant Vesicles

In: Giant Vesicles, Perspectives in Supramol. Chemistry (Luisi P.L., Walde P., eds), John Wiley & Sons Ltd., Chichester, 261-270, 2000


346. T.Oberholzer, A. Fischer

Microinjection of Macromolecules in Giant Vesicles Prepared by Electroformation

In: Giant Vesicles, Perspectives in Supramol. Chemistry (Luisi P.L., Walde P., eds), John Wiley & Sons Ltd., Chichester, 285-295, 2000


347. P.L. Luisi

Intreccio di tempo ciclico e tempo lineare nel mondo biologico

In: E il futuro già dato? Alfr.Guida Ed. Napoli 69-88, 2000


348. H.H. Zepik, E. Blöchliger, P.L. Luisi

A Chemical Model of Homeostasis

Angew.Chemie Int.Ed. 40 No.1, 199-202, 2001


349. J.W. Szostak, D.P. Bartel, P.L. Luisi

Synthesizing Life

Nature 409, 387-390, 2001


350. M. Schuleit, P.L. Luisi

Enzyme Immobilization in Silica-Hardened Organogels

Biotechn. & Engin. 72, 249-253, 2001


351. N. Berclaz, M. Müller, P. Walde, P.L. Luisi

Growth and Transformation of Vesicles Studied by Ferritin Labeling and Cryotransmission Electron Microscopy

J.Phys.Chem.B 105, 1056-1064, 2001


352. N. Berclaz, E. Blöchliger, M. Müller, P.L. Luisi

Matrix Effect of Vesicle Formation as Investigated by Cryotransmission Electron Microscopy

J.Phys.Chem.B 105, 1065-1071, 2001


353. P.L. Luisi

Are Micelles and Vesicles Chemical Equilibrium Systems?

J.Chem.Ed. 78, 380-384, 2001


354. R.M. Thomas, J.W. Vrijbloed, P.L. Luisi

Towards Random Polypeptide Synthesis

Chimia 55 114-118, 2001


355. T.Hitz, M. Blocher, P. Walde, P.L. Luisi

Stereoselectivity Aspects in the Condensation of Racemic NCA-Amino Acids in the presence and Absence of Liposomes

Macromolecules 34, 2443-2449, 2001


356. T. Hitz, P.L. Luisi

Liposome-Assisted Selective Polycondensation of a-Amino Acids and Peptides

Biopolymers (Peptide Science) 55, 381-390, 2001


357. M. Blocher, T. Hitz, P.L. Luisi

Stereoselectivity in the Oligomerization of Racemic Tryptophan N-Carboxyanhydride (NCA-Trp) as Determined by Isotope Labeling and Mass Spectrometry

Helvetica Chimica Acta 84, 842-848, 2001


358. L.D. Schuler, P. Walde, P.L. Luisi, W.F. vanGunsteren

Molecular Dynamics Simulation of n-dodecyl phosphate aggregate structures

Eur. Biophysics J. 30, 330,343, 2001.


359. H. Fukuda, A. Goto, H. Yoshioka, R. Goto, K. Morigaki, P. Walde

Electron Spin Resonance Study of the pH-Induced Transformation of Micelles to Vesicles in an Aqueous Oleic Acid/Oleate System

Langmuir 17, 4223-4231, 2001


360. P. Walde, S. Ichikawa

Enzymes inside Lipid Vesicles: preparation, reactivity and Applications

Biomolecular Engineering 18, 143-177, 2001



363. R.M. Thomas, D.J. Curtis

A Novel Software Application for the Study of Photoperiodic Cueing Mechanisms Underlying Circadian and Circannual Rhythms and Lunar-Periodic Modulations

Folia Primatol. 72, 187, 2001


364. R.E. Smith, S. Burmaster, A.G. Glaros, J.D. Eick, P. Walde, E.L. Kostoryz, D.M. Yourtee

Aromatic dental monomers affect the activity of cholesterol esterase

Biochimica et Biophysica Acta, 1550, 100-16 2001


365. P.L. Luisi, T. Oberholzer

Origin of life on Earth: Molecular Biology in Liposomes as an Approach to the Minimal Cell

In: The Bridge between the Big Bang and Biology, F. Giovanelli (ed.), CNR Pres., 345-355 2001


366. K. Conde-Frieboes, E. Blöchliger

Synthesis of lipids on the micelle/water interface using inorganic phosphate and an alkene oxide

BioSystems 61, 109-114 2001



368. G. Zandomeneghi, P.L. Luisi, L. Mannina, A. Segre

NMR Study of Micelles Formed by Monoalkylphosphoryl Nucleosides

Helvetica Chimica Acta, 84, 3710-3725 2001


369. P. Walde, P.L. Luisi (Hrsg.)

Vom Ursprung des Lebens

vdf Hochschulverlag AG, Zürich 2002


370. P.L. Luisi

Die Frage nach der Entstehung des Lebens auf der Erde aus der Sicht der molekularen Naturwissenschaften

In: Vom Ursprung des Lebens, P.Walde, P.L. Luisi (Hrsg.), vdf Hochschulverlag AG Zürich, 2002


371. R.M. Thomas, A. Baici, M. Werder, G. Schulthess, H. Hauser

Kinetics and Mechanism of Long-Chain Fatty Acid Transport into Phosphatidylcholine Vesicles from Various Donor Systems

Biochemistry, 41, 1591-1601 2002


372. M. Treyer, P. Walde, Th. Oberholzer

Permeability Enhancement of Lipid Vesicles to Nucleotides by Use of Sodium Cholate: Basic Studies and Application to an Enzyme-Catalyzed Reaction Occurring inside the Vesicles

Langmuir, 18, No. 4, 1043-1050, 2002


373. A.V. Pietrini, P.L. Luisi

Circular dichroic properties and average dimensions of DNA-containing reverse micellar aggregates

Biochimica et Biophysica Acta, 1562, 57-62 2002


374. P.L. Luisi, Th. Oberholzer, A. Lazcano

The Notion of a DNA Minimal Cell: A General Discourse and Some Guidelines for an Experimental


Helvetica Chimica Acta, 85, No. 6, 1759-1777 2002


375. P.L. Luisi

Emergence in Chemistry: Chemistry as the Embodiment of Emergence

Foundations of Chemistry, 4, No. 3, 183-200 2002


376. K. Morigaki, P. Walde

Giant Vesicle Formation from Oleic Acid/Sodium Oleate on Glass Surfaces Induced by Adsorbed Hydrocarbon Molecules

Langmuir, 18, 10509-10511, 2002


377. A.S. Domazou, P.L. Luisi

Size Distribution of Spontaneously Formed Liposomes by the Alcohol Injection Method

Journal of Liposome Research, 12, No. 3, 205-220 2002


378. Th. Hitz, P.L. Luisi

Enhancement of Homochirality in Oligopeptides by Quartz

Helv.Chim.Acta, 85, 3975-3883 2002


379. P.L. Luisi

Toward the Engineering of Minimal Living Cells

The Anatomical Record, 268, No. 3, 208-214 2002


380. P.L. Luisi

Some open questions about the origin of life

In: Fundamentals of Life, Elsevier Paris, ISBN 2-84299-303-9, 287-301, 2002


381. T. Oberholzer, P.L. Luisi

The Use of Lipsomes for Constructing Cell Models

In: Journal of Biological Physics 28, 733-744, 2002


382. T. Oberholzer

Nucleic Acid-Dependent Enzymatic Reactions in Conventional Liposomes and Giant Vesicles

In: CRC Handbook of Surface and Colloid Chemistry, K. S. Birdi (ed.), ISBN 0849310792, August 2002, pp 611-622


383. A. Fischer, A. Franco, T. Oberholzer

Giant Vesicles as Microreactors for Enzymatic mRNA Synthesis

ChemBioChem 3, 409-417, 2002


384. K. Morigaki, P. Walde, M. Misran, B.H. Robinson

Thermodynamic and kinetic stability. Properties of micelles and vesicles formed by the decanoic acid/decanoate system

Colloid and Surfaces A: Physiocochem. Eng. Aspects 213, 37-44, 2003



386. P.L. Luisi

Autopoiesis: a review and a reappraisal

In: Naturwissenschaften, Springer Verlag, 90, No. 2, 49-59, 2003


387. T. Hitz, P.L. Luisi

Chiral Amplification of Oligopeptides in the Polymerization of a-Amino Acid N-Carboxyanhydrides in Water

Helv. Chim. Acta 86, 1423-1434, 2003


388. P.L. Luisi

Contingency and Determinism

The Royal Society, Phil. Trans. R. Soc. Lond. A, 361, 1141-1147, 2003


389. Cheng, Z.; Luisi, P.L.

Coexistence and mutual competition of vesicles with different size distributions.

J. Phys. Chem. B 2003, 107 (39), 10940-10945.


390. Rasi, S.; Mavelli, F.; Luisi, P.L.

Cooperative micelle binding and matrix effect in oleate vesicle formation.

J. Phys. Chem. B 2003, 107 (50), 14068-14076.


391. Walde, P.

Pier Luigi Luisi retires from the ETH.

Chimia 2003, 57 (7-8), 471-474.


391(b). Walde, P.

Preparation of Vesicles (Liposomes)

ASP Encyclopedia of Nanoscience and Nanotechnology (2003), Ed. H. S. Nalwa, Vol. 9, 43-79.


392. Kato, K.; Walde, P.; Mitsui, H.; Higashi, N.

Enzymatic activity and stability of D-fructose dehydrogenase and sarcosine dehydrogenase immobilized onto giant vesicles.

Biotechnol. Bioeng. 2003, 84 (4), 415-423.



394. Islas, S.; Becerra, A.; Luisi, P.L.; Lazcano, A.

Comparative genomics and the gene complement of a minimal cell.

Origins Life Evol. Biosph. 2004, 34 (1-2), 243-256.


395. Rasi, S.; Mavelli, F.; Luisi, P.L.

Matrix effect in oleate micelles-vesicles transformation.

Origins Life Evol. Biosph. 2004, 34 (1-2), 215-224.


396. Hitz, T.; Luisi, P.L.

Spontaneous onset of homochirality in oligopeptide chains generated in the polymerization of N-carboxyanhydride amino acids in water.

Origins Life Evol. Biosph. 2004, 34 (1-2), 93-110.


397. Luisi, P.L.


Origins Life Evol. Biosph. 2004, 34 (1-2), 1-2.


398. Cruciani, O.; Mannina, L.; Sobolev, A. P.; Segre, A.; Luisi, P. L.

Multilamellar Liposomes Formed by Phosphatidyl Nucleosides: An NMR-HR-MAS Characterization.

Langmuir 2004, 20 (4), 1144-1151.


399. Luisi, P. L.; Stano, P.; Rasi, S.; Mavelli, F.

A Possible Route to Prebiotic Vesicle Reproduction.

Artificial Life 2004, 10 (3), 297-308.


400. Pietrini, A. V.; Luisi, P. L.

Cell-free Protein Synthesis through Solubilisate Exchange in Water/Oil Emulsion Compartments.

ChemBioChem 2004, 5, 1055-1062.


401. Thomas, C. F.; Luisi, P. L.

Novel Properties of DDAB: Matrix Effect and Interaction with Oleate.

J. Phys. Chem. B 2004, 108, 11285-11290.


402. Stano, P.; Bufali, S.; Pisano, C.; Bucci, F.; Barbarino, M.; Santaniello, M.; Carminati, P.; Luisi, P. L.

Novel Camptothecin Analogue (Gimatecan)-containing Liposomes prepared by the Ethanol Injection Method.

J. Liposome Research 2004, 14 (1-2), 87-109.



405. Bitbol, M.; Luisi, P. L.

Autopoiesis with or without cognition: defining life at its edge.

J. R. Soc. Interface 2004, 1, 99-107.

Pier Luigi Luisi

Pier Luigi received his scientific education at the Scuola Normale Superiore in Pisa, Italy. In 1970, he became professor at the Institut für Polymere at the ETH-Zürich and since 2006 he is part of the biology department of the University of Roma Tre. As a biochemist, he pioneered an active research in the self-organization of synthetic and biological systems, the origin of life, and semi-synthetic cellular systems (the so-called "mininal life"). Interested in the interface between science and humanities, in 1985 he founded Cortona week, legacy to this Todi-week, and participated, in 1987, to the foundation of Mind and Life in Dharamsala, India, with Francisco Varela and the Dalai Lama.

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